The main border between the United States and Mexico is which river?.
Rio Grande River.
2023 July
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In most of Texas, the Rio Grande River, which spans 3,051 kilometers and runs from Colorado to the Gulf of Mexico, acts as the primary border between the United States and Mexico. The state of Texas and its Republican governor, Greg Abbott, have recently been sued by the US Justice Department for building floating barriers in the Rio Grande River to block migrants from entering the country from Mexico.